Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

GPCR Desensitization01:12

GPCR Desensitization

G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Anatomical Terminology01:20

Anatomical Terminology

Knowledge of anatomy is essential to understand human biology and medicine. Anatomists and health care professionals use standard terminology to describe the human body with more precision and no ambiguity. Anatomical terms have mostly Greek and Latin-derived roots. Because these languages are rarely used in conversation, the meaning of words remains the same. Each term is made up of a root in between the prefixes and suffixes. The root of a term often refers to an organ, tissue, or condition,...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of phenotype algorithms for the detection of adverse events in electronic health record data: a multicentre study.

BMJ open·2026
Same author

Children born SGA receiving growth hormone have similarly impaired glucose-insulin metabolism as children with obesity.

The Journal of clinical endocrinology and metabolism·2026
Same author

The CrescNet Registry Achondroplasia Module: Real-World Demographic Data and Clinical Outcomes in Untreated and Vosoritide-Treated Individuals.

Hormone research in paediatrics·2026
Same author

GeMTeX's De-Identification in Action: Lessons Learned & Devil's Details.

Studies in health technology and informatics·2025
Same author

A Weighted Voting Approach for Traditional Chinese Medicine Formula Classification Using Large Language Models: Algorithm Development and Validation Study.

JMIR medical informatics·2025
Same author

Real-World Safety and Effectiveness of Vosoritide in Achondroplasia: Results from a Single Center in Portugal.

Advances in therapy·2025
Same journal

The Essential Components and Critical Conditions for Success in a Learning Health System in Oncology.

Studies in health technology and informatics·2026
Same journal

Use of Artificial Intelligence in Screening for Adolescent Idiopathic Scoliosis: A Scoping Review.

Studies in health technology and informatics·2026
Same journal

Movement Related Biomechanics in Adolescent Idiopathic Scoliosis: A Review of Reviews.

Studies in health technology and informatics·2026
Same journal

The Impact of Surgical Correction of Adolescent Idiopathic Scoliosis Using Posterior Spinal Fusion on Selected Radiological Parameters and Respiratory Function.

Studies in health technology and informatics·2026
Same journal

Acute Effect of Physio-logic® Exercises on Muscle Tone and Stiffness in Adolescent Idiopathic Scoliosis Patients: A Preliminary Study.

Studies in health technology and informatics·2026
Same journal

Effects of Integrated Music and Occupational Therapy on Motor and Autonomic Function in Children with Neurogenic Scoliosis.

Studies in health technology and informatics·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

GFO-Light: A Simplified Top-Level Ontology - Introduction and Biomedical Case Studies.

Ralph Schäfermeier1, Frank Loebe2, Patryk Burek3

  • 1Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University.

Studies in Health Technology and Informatics
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

A new lightweight top-level ontology, GFO-light, is introduced for easier use by non-experts. It balances expressivity and accessibility, incorporating features from the General Formal Ontology for diverse applications.

Keywords:
ClassificationInteroperabilitySemanticsTerminology

More Related Videos

Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence
11:51

Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence

Published on: April 27, 2018

Related Experiment Videos

Last Updated: May 24, 2026

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence
11:51

Engineering 'Golden' Fluorescence by Selective Pressure Incorporation of Non-canonical Amino Acids and Protein Analysis by Mass Spectrometry and Fluorescence

Published on: April 27, 2018

Area of Science:

  • Ontology Engineering
  • Formal Ontology
  • Knowledge Representation

Background:

  • Traditional top-level ontologies (TLOs) often feature complex axiomatizations and philosophical jargon, limiting accessibility for domain experts.
  • Lightweight TLOs aim to bridge the gap between expressivity and usability, catering to users without extensive formal ontology expertise.
  • The General Formal Ontology (GFO) offers unique features like integrated objects and processes within continuous spacetime.

Purpose of the Study:

  • To introduce GFO-light, a novel lightweight TLO designed for enhanced usability by non-ontologists.
  • To balance expressivity and accessibility, making formal ontology concepts more approachable for domain experts.
  • To incorporate key features of the General Formal Ontology (GFO) and common modeling patterns into a more accessible framework.

Main Methods:

  • Derivation of GFO-light from the established General Formal Ontology (GFO).
  • Ontological and representational choices guided by real-world use cases and common modeling patterns.
  • Focus on accommodating existing GFO features while prioritizing ease of use.

Main Results:

  • Development of GFO-light, a novel lightweight top-level ontology.
  • GFO-light successfully balances ease of use with expressiveness.
  • The ontology includes widely used features often absent in other lightweight TLOs.

Conclusions:

  • GFO-light offers a practical solution for broader adoption of formal ontology principles.
  • The lightweight approach enhances accessibility for domain experts without sacrificing essential ontological expressivity.
  • This TLO facilitates knowledge representation by integrating objects, processes, and spacetime concepts effectively.