Regulated cell death: a multidimensional regulatory network in the pathogenesis of renal fibrosis

Area of Science:

• Nephrology
• Cell Biology
• Pathology

Background:

• Regulated cell death (RCD) pathways, including apoptosis, pyroptosis, and ferroptosis, are increasingly implicated in renal tissue injury and fibrosis.
• These processes promote inflammation and extracellular matrix deposition, driving kidney fibrosis progression.

Purpose of the Study:

• To comprehensively review the distinct and interactive roles of various RCDs in renal fibrosis pathogenesis.
• To elucidate the crosstalk between different RCDs and fibrotic signaling pathways.
• To identify promising RCD-related therapeutic targets for renal fibrosis.

Main Methods:

• Literature review and synthesis of existing research on RCD and renal fibrosis.
• Analysis of molecular mechanisms underlying RCD in kidney injury.
• Evaluation of therapeutic strategies targeting RCD pathways.

Main Results:

• RCD plays a critical role in renal fibrosis through inflammatory responses and extracellular matrix deposition.
• Complex crosstalk exists among different RCD pathways and core fibrotic signaling.
• Several RCD-related targets show clinical promise for treating renal fibrosis.

Conclusions:

• Understanding RCD mechanisms is crucial for developing effective treatments for renal fibrosis.
• Simultaneous targeting of multiple RCD pathways may overcome compensatory crosstalk for precise therapeutic intervention.
• Further research is needed to translate these findings into clinical practice for renal fibrosis patients.