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Simultaneous Intracranial Angiography and Susceptibility Imaging (SIAS) by Combining Velocity-Selective ASL and

Lixin Liu1, Ying-Hua Chu2, Lili Wang1

  • 1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.

Magnetic Resonance in Medicine
|May 25, 2026
PubMed
Summary

A new simultaneous intracranial angiography and susceptibility imaging (SIAS) sequence enhances visualization of small cerebral arteries and veins. This method improves diagnostic capabilities for brain disorders, offering efficient and comprehensive assessment.

Keywords:
cerebrovascular imagingmagnetic resonance angiographyquantitative susceptibility mappingsusceptibility‐weighted imagingvelocity‐selective arterial spin labeling

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Intracranial angiography and susceptibility imaging are crucial for diagnosing cerebral disorders.
  • Current methods may have limitations in visualizing distal vessels and differentiating arteries from veins.

Purpose of the Study:

  • To develop a simultaneous intracranial angiography and susceptibility imaging (SIAS) sequence.
  • To achieve high acquisition efficiency and improve visualization of distal cerebral vessels.

Main Methods:

  • SIAS integrates multi-echo susceptibility-weighted imaging (SWI) within velocity-selective arterial spin labeling (VSASL) MRA.
  • Sequence parameters were optimized in volunteers, and SIAS was compared to conventional VSASL, TOF, and SWI.
  • A susceptibility-guided strategy was used for artery-vein separation.

Main Results:

  • SIAS-VSASL visualized distal arteries better than TOF and improved proximal artery sharpness over VSASL.
  • SIAS-SWI provided sharper vein depiction and reliable susceptibility quantification.
  • Susceptibility-guided post-processing enabled effective artery-vein separation.

Conclusions:

  • SIAS offers excellent visualization of small arteries and supports hemorrhage detection and quantitative susceptibility mapping.
  • The sequence facilitates artery-vein separation, crucial for diagnosing complex brain disorders.
  • SIAS shows significant potential for comprehensive brain disorder assessment.