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Nearest Neighbor Parameters for Estimating the Folding Stability of RNA Including Pseudouridine

Thandolwethu S Shabangu1, Elzbieta Kierzek2, Sebastian Arteaga3

  • 1Department of Biochemistry & Biophysics and Center for RNA Biology, University of Rochester Medical Center, Rochester, New York 14526, USA.

Biorxiv : the Preprint Server for Biology
|May 25, 2026
PubMed
Summary

This study introduces new parameters for predicting RNA folding stability with pseudouridine, a modified nucleotide. These parameters, based on optical melting experiments, improve accuracy for RNA structures containing pseudouridine.

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