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Successful Scale-up of Syphilis Testing Linked to Routine HIV Viral Load Monitoring in British Columbia.
Kyle A Thompson1, Matthew Clifford-Rashotte2, Wendy Zhang1
1BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Open Forum Infectious Diseases
|May 25, 2026
Summary
Syphilis screening increased among people with HIV in British Columbia from 2015-2019, linked to routine viral load tests. Frequent testing was associated with key demographics and care factors.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- HIV/AIDS Research
Background:
- Rising syphilis rates globally necessitate effective screening strategies.
- Inadequate syphilis testing poses a significant public health challenge, particularly among vulnerable populations.
- People living with human immunodeficiency virus (HIV) are at increased risk for syphilis co-infection.
Purpose of the Study:
- To examine syphilis screening trends among people living with HIV in British Columbia between 2015 and 2019.
- To identify factors associated with the frequency of syphilis testing in this population.
Main Methods:
- Retrospective analysis of syphilis screening data for individuals with HIV in British Columbia.
- Statistical analysis to determine trends and associations over the study period (2015-2019).
Main Results:
- Syphilis testing among people with HIV significantly increased between 2015 and 2019.
- Increased testing was strongly correlated with routine human immunodeficiency virus (HIV) viral load monitoring.
- Frequent syphilis screening was associated with men who have sex with men, residence in Vancouver, and engagement with HIV-focused care.
Conclusions:
- Routine HIV viral load monitoring can be an effective strategy to increase syphilis screening frequency.
- Targeted interventions may be needed to ensure equitable syphilis screening for all people with HIV.
- Understanding demographic and care-related associations can inform public health strategies to combat syphilis co-infection.

