Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 28, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

Surface-Modified Extrinsic Semi-Distributed Interferometers for Fiber-Optic Refractive Index Detection and

Albina Abdossova¹, Toheeb Olalekan Oladejo¹, Sabira Seipetdenova¹

¹School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.

|May 26, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Magnetically Targeted Drug Transport Across a Tumor Cell Membrane Under Magnetic Field Gradients.

International journal of molecular sciences·2026

Same author

State-of-the-Art and Next Generation Intra-Articular Implantable Biosensors for Osteoarthritis: From Analytical Limits to Operational Stability.

Biosensors·2026

Same author

Therapeutic potential of TAM receptors in autoimmune diseases: insights from original studies.

Oxford open immunology·2026

Same author

Hydrogels for Osteochondral Interface Regeneration: Biomaterial Types, Processes, and Animal Models.

Gels (Basel, Switzerland)·2026

Same author

Functionalization Techniques Empowering Optical Fiber Biosensors in Label-Free Cancer Biomarker Detection.

Biosensors·2026

Same author

Digging into the Solubility Factor in Cancer Diagnosis: A Case of Soluble CD44 Protein.

Biosensors·2025

Same journal

A Coumarin-Based Probe for Sequential ON-OFF-ON Detection of Cu<sup>2+</sup> and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging.

Biosensors·2026

Same journal

Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.

Biosensors·2026

Same journal

Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Biosensors·2026

Same journal

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data.

Biosensors·2026

Same journal

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026

Same journal

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026

See all related articles

This summary is machine-generated.

This study introduces an extrinsic semi-distributed interferometer (ESDI) for enhanced refractive index sensing. Gold-nanoparticle-coated ESDIs show high sensitivity and resolution, with potential for biological applications like VEGF detection.

Area of Science:

Photonics and Sensing Technologies
Nanomaterials Science
Biomedical Engineering

Background:

Semi-distributed interferometers offer refractive index sensing by utilizing random reflectivity in nanoparticle-doped fibers.
Extending this, an extrinsic semi-distributed interferometer (ESDI) is proposed using a polydimethylsiloxane (PDMS) overlay on a fiber tip.

Purpose of the Study:

To develop and characterize gold-sputtered and gold-nanoparticle-coated ESDI structures for enhanced refractive index sensing.
To explore the potential of biofunctionalized ESDI probes for detecting specific biomolecules, such as vascular endothelial growth factor (VEGF).

Main Methods:

Fabrication of extrinsic semi-distributed interferometers (ESDI) with PDMS overlays.
Surface modification of ESDI structures with gold sputtering and gold nanoparticle coating.

Keywords:

interferometry optical fiber sensors refractive index sensor semi-distributed interferometer thin-film coating

More Related Videos

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response

Published on: January 7, 2019

A Random-displacement Measurement by Combining a Magnetic Scale and Two Fiber Bragg Gratings

A Random-displacement Measurement by Combining a Magnetic Scale and Two Fiber Bragg Gratings

Published on: September 30, 2019

Related Experiment Videos

Last Updated: May 28, 2026

Implementation of a Reference Interferometer for Nanodetection

Implementation of a Reference Interferometer for Nanodetection

Published on: April 26, 2014

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response

Published on: January 7, 2019

A Random-displacement Measurement by Combining a Magnetic Scale and Two Fiber Bragg Gratings

A Random-displacement Measurement by Combining a Magnetic Scale and Two Fiber Bragg Gratings

Published on: September 30, 2019

Performance evaluation for refractive index sensing, including sensitivity and resolution.

Biofunctionalization of gold-sputtered probes for VEGF detection and sensitivity analysis.

Main Results:

Gold-nanoparticle-coated ESDIs demonstrated superior refractive index sensing with an average sensitivity of 62.8 dB/RIU and a resolution of 3.9 × 10^-5 RIU.
The refractive index sensing range was determined to be 1.34790-1.35981.
Biofunctionalized gold-sputtered probes achieved a sensitivity of 0.0565 dB per 10× concentration increase for VEGF detection, with a limit of detection at 355 fM.

Conclusions:

Extrinsic semi-distributed interferometers, particularly those coated with gold nanoparticles, offer a promising platform for high-performance refractive index sensing.
The developed biofunctionalized probes show significant potential for sensitive and specific detection of biomarkers like VEGF in biological applications.