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RETRACTED: Dukenbayev et al. Fe<sub>3</sub>O<sub>4</sub> Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy. <i>Nanomaterials</i> 2019, <i>9</i>, 494.

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Magnetically Targeted Drug Transport Across a Tumor Cell Membrane Under Magnetic Field Gradients.

Milan S Kovačević1,2, Relja Dragnić1, Vladimir M Marković1

  • 1Department of Physics, Faculty of Science, University of Kragujevac, 34000 Kragujevac, Serbia.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary

Magnetic targeting enhances drug delivery to tumor cells by increasing drug accumulation near the cell membrane. This method amplifies biological differences, improving drug transport efficiency across cell membranes.

Keywords:
magnetic Peclet numbermagnetic drug targetingmagnetophoretic drifttransmembrane drug transporttumor cell membrane

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Area of Science:

  • Biophysics
  • Cellular Biology
  • Nanotechnology

Background:

  • Magnetic targeting of drug carriers is typically studied at macroscopic scales.
  • The impact of magnetic targeting on drug transport across individual cell membranes is poorly quantified.

Purpose of the Study:

  • To develop a theoretical and numerical model for magnetically assisted drug transport across a single tumor cell membrane.
  • To quantify the effects of magnetic field gradients on drug delivery at the cellular level.

Main Methods:

  • A theoretical and numerical model was developed using advection-diffusion equations coupled with magnetophoretic drift.
  • Finite-difference schemes were employed to solve coupled transport equations with spherical symmetry.
  • The model incorporated membrane permeability and intracellular uptake kinetics to differentiate between healthy and tumor cells.

Main Results:

  • Magnetophoretic drift was found to enhance near-membrane drug accumulation and transmembrane flux.
  • Magnetic targeting acts as a transport amplifier, magnifying biological differences between cell types.
  • The magnetic Peclet number was identified as the key parameter for drift-enhanced cellular drug transport.

Conclusions:

  • Magnetically assisted drug transport significantly improves drug delivery efficiency at the single-cell level.
  • The model provides a framework for understanding and optimizing magnetic targeting strategies for cancer therapy.
  • Magnetic targeting can enhance therapeutic outcomes by exploiting and amplifying cellular heterogeneity.