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Published on: May 26, 2023
Lipidomic Signatures in Feline Disease: A PRISMA-Guided Systematic Review
Ana Carolina Fontes1, Carolina Santos Silva1,2, Ana Carolina Matos1
1Department of Veterinary Sciences, School of Agricultural and Veterinary Sciences (ECAV), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Metabolites
|May 26, 2026
Summary
Feline lipidomics reveals significant lipid alterations in diseases like hepatic lipidosis and obesity, offering potential diagnostic value. Further research is needed to validate these lipid signatures for clinical use in cats.
Area of Science:
- Veterinary Medicine
- Systems Biology
- Metabolomics
Background:
- Lipidomics is crucial for understanding metabolic dysfunction in systems biology.
- Lipid metabolism is central to feline diseases like hepatic lipidosis, obesity, and diabetes mellitus.
- Feline lipidomics data is currently limited, hindering disease characterization.
Purpose of the Study:
- To systematically review current evidence on lipidomics and lipid-focused profiling in feline disease.
- To identify lipid alterations with potential clinical relevance in cats.
Main Methods:
- Systematic literature search following PRISMA 2020 guidelines (PubMed, ScienceDirect, Scopus).
- Inclusion of original studies (1994-2026) evaluating lipid species, fatty acids, or lipoproteins in feline disease.
- Narrative synthesis of findings due to methodological heterogeneity.
Main Results:
- Seventeen studies covered various feline conditions, noting alterations in lipoproteins, triglycerides, phospholipids, sphingolipids, fatty acids, and oxylipins.
- Distinct lipid patterns were observed in hepatic lipidosis (lipoprotein disturbances), lower urinary tract disease (oxylipins), and obesity (phospholipid/triglyceride shifts).
- Fatty acid and sphingolipid changes correlated with inflammation and disease severity in enteropathies and neurological conditions, respectively.
Conclusions:
- Feline lipidomics demonstrates biologically meaningful alterations with emerging diagnostic and prognostic potential.
- Lipid-focused approaches can enhance feline disease characterization and support translational research.
- Standardized studies and reference datasets are essential for clinical implementation of feline lipid signatures.
