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Updated: May 28, 2026

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High-Stability Wool-Based Single-Helix Artificial Muscles via Dithiol-Mediated Disulfide Rebonding.

Yujin Han1, Yingzhen Zhou1, Siyu Meng1

  • 1College of Textile Science and Engineering, Jiangnan University, Wuxi 214122, China.

ACS Biomaterials Science & Engineering
|May 26, 2026
PubMed
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Researchers chemically immobilized single-helix wool artificial muscles using disulfide bond reactions. This enhanced stability and enabled reversible actuation under heat or water, showing potential for smart bionic devices.

Area of Science:

  • Materials Science
  • Biomaterials Engineering
  • Textile Science

Background:

  • Single-helix wool artificial muscles offer scalability but lack stability due to reliance on hydrogen bonds.
  • Chemical modification is needed to overcome inherent instability and enhance performance.

Purpose of the Study:

  • To chemically immobilize single-helix wool artificial muscles using disulfide bond chemistry.
  • To improve structural stability, thermal properties, and actuation performance.
  • To explore a dual-switch actuation mechanism for advanced applications.

Main Methods:

  • Utilized disulfide bond cleavage-repair reaction with dithiothreitol (DTT).
  • Prepared R-St-C-O wool yarn for enhanced properties.
  • Analyzed structural changes using Raman spectroscopy and X-ray diffraction.
Keywords:
DTTartificial muscledisulfide bondsingle-helixwool yarns

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Last Updated: May 28, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Published on: August 1, 2018

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Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture

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Main Results:

  • Achieved stable, single-helix wool artificial muscles with improved shape and thermal stability.
  • Increased disulfide bond content by ~24% and breaking strength by 20%.
  • Demonstrated reversible actuation under wet-heat conditions and programmable shaping via UV/reductant treatment.

Conclusions:

  • Chemically immobilized wool artificial muscles exhibit enhanced stability and dual-switch actuation.
  • The developed material shows significant potential for bionic actuators and smart controllers.
  • The study presents a scalable method for creating robust artificial muscles from wool.