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Updated: May 28, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
From germline immortality to somatic rejuvenation: Unlocking the ovarian blueprint for longevity
Priscila Chiavellini1,2, Vittorio Sebastiano1,2
1Department of Biological Chemistry, Center for Epigenetics and Metabolism, Stem Cell Research Center, University of California, Irvine, Irvine, California, United States of America.
Abstract:
Aging is typically framed as a one-way, irreversible accumulation of molecular damage in cells and tissues, leading to progressive functional decline. Yet mammalian reproduction, and particularly female reproduction, reveals a striking exception to this rule. Despite residing within an aging organism and within a fast-aging ovarian tissue environment, oocytes give rise to embryos that begin life with restored developmental potential and youthful molecular organization. By reframing ovarian biology as a model for rejuvenation rather than solely as a site of reproductive decline, this Essay proposes that the ovary offers a powerful blueprint for advancing the biology of aging and longevity.
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