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Updated: May 28, 2026

A Practical Guide to Phage- and Robotics-Assisted Near-Continuous Evolution

A Practical Guide to Phage- and Robotics-Assisted Near-Continuous Evolution

Published on: January 12, 2024

Advances in protein engineering.

Huong Lan Vuong¹, Hien Thi Thu Le²

¹National Hospital for Tropical Disease, Pharmacy Department, Hanoi, Vietnam.

International Review of Cell and Molecular Biology

|May 26, 2026

Summary

Protein engineering advances human disease treatment, particularly in cancer therapeutics. This review covers innovative techniques and key achievements in protein design for biomedical applications.

Keywords:

Mutations Protein engineering Protein structures Synthetic biology

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Area of Science:

Biotechnology
Biomedical Sciences
Protein Engineering

Background:

Protein engineering (PE) has yielded significant advancements in medicine, food, and environmental applications.
Notable successes include protein therapeutics, antibody engineering, and enzyme synthesis.
PE plays a crucial role in developing specific functions for industrial processes.

Purpose of the Study:

To highlight recent protein engineering advances against human diseases and in biomedical sciences.
To review innovative protein design techniques such as evolution, rational design, semi-rational design, and hybrid approaches.
To discuss key achievements, challenges, ethical considerations, and therapeutic approaches in PE.

Main Methods:

Review of recent literature on protein engineering applications.
Focus on innovative techniques: evolution, rational design, semi-rational design, and hybrid approaches.
Examination of PE achievements in CRISPR/Cas systems, high-throughput data, and synthetic biology.

Main Results:

PE demonstrates transformative potential in human disease treatment, especially cancer therapeutics.
Innovative techniques are driving progress in protein design and application.
Key achievements in CRISPR/Cas systems, high-throughput data, and synthetic biology are presented.

Conclusions:

Protein engineering offers a powerful toolkit for addressing human diseases.
Continued research and ethical considerations are vital for advancing protein therapeutics.
PE is poised to revolutionize biomedical sciences and therapeutic development.