Related Experiment Video
Updated: May 28, 2026
06:24
Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
Published on: October 13, 2023
CXCL14 Inhibits Colon Cancer Progression by Modulating Tumor Cell Invasion and Immune Microenvironment
Yinjie Zhang1,2, Siyi Wang1, Yuchen Niu1
1School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Cells
|May 27, 2026
Summary
Chemokine CXCL14 inhibits colon cancer progression by suppressing tumor cell growth and metastasis. It also enhances anti-tumor immunity by converting the tumor microenvironment from cold to hot, making it a promising immunotherapy target.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- CXCL14 is a conserved chemokine implicated in tumor progression and immune modulation.
- Its precise role in colon cancer remains to be fully elucidated.
Purpose of the Study:
- To investigate the functional impact of CXCL14 on colon cancer cell behavior and the tumor immune microenvironment.
- To explore CXCL14 as a potential therapeutic target for colon cancer.
Main Methods:
- Generation of stable cell lines overexpressing CXCL14 in mouse and human colon cancer cells.
- Assessment of tumor growth, invasion, and metastasis in vitro and in vivo.
- Analysis of immune cell infiltration, gene expression (RNA sequencing), and signaling pathways (MAPK).
Main Results:
- CXCL14 overexpression suppressed colon cancer cell proliferation, migration, and metastasis.
- CXCL14 inhibited matrix metalloproteinases (MMPs) and promoted mesenchymal-epithelial transition (MET).
- In vivo, CXCL14 enhanced anti-tumor immune cell infiltration (NK, DCs, T cells), shifting the tumor microenvironment to a 'hot' phenotype and reducing metastasis.
Conclusions:
- CXCL14 inhibits colon cancer progression by modulating tumor cell behavior and enhancing anti-tumor immunity.
- CXCL14 is a promising candidate for targeted immunotherapy in colon cancer.
- Findings provide insights into CXCL14's therapeutic potential for enhancing anti-tumor immunity.
Related Concept Videos
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...