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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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CXCL14 Inhibits Colon Cancer Progression by Modulating Tumor Cell Invasion and Immune Microenvironment.

Yinjie Zhang1,2, Siyi Wang1, Yuchen Niu1

  • 1School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

Cells
|May 27, 2026
PubMed
Summary
This summary is machine-generated.

Chemokine CXCL14 inhibits colon cancer progression by suppressing tumor cell growth and metastasis. It also enhances anti-tumor immunity by converting the tumor microenvironment from cold to hot, making it a promising immunotherapy target.

Keywords:
CXCL14colorectal carcinomaepithelial–mesenchymal transitionimmuno-microenvironment

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07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • CXCL14 is a conserved chemokine implicated in tumor progression and immune modulation.
  • Its precise role in colon cancer remains to be fully elucidated.

Purpose of the Study:

  • To investigate the functional impact of CXCL14 on colon cancer cell behavior and the tumor immune microenvironment.
  • To explore CXCL14 as a potential therapeutic target for colon cancer.

Main Methods:

  • Generation of stable cell lines overexpressing CXCL14 in mouse and human colon cancer cells.
  • Assessment of tumor growth, invasion, and metastasis in vitro and in vivo.
  • Analysis of immune cell infiltration, gene expression (RNA sequencing), and signaling pathways (MAPK).

Main Results:

  • CXCL14 overexpression suppressed colon cancer cell proliferation, migration, and metastasis.
  • CXCL14 inhibited matrix metalloproteinases (MMPs) and promoted mesenchymal-epithelial transition (MET).
  • In vivo, CXCL14 enhanced anti-tumor immune cell infiltration (NK, DCs, T cells), shifting the tumor microenvironment to a 'hot' phenotype and reducing metastasis.

Conclusions:

  • CXCL14 inhibits colon cancer progression by modulating tumor cell behavior and enhancing anti-tumor immunity.
  • CXCL14 is a promising candidate for targeted immunotherapy in colon cancer.
  • Findings provide insights into CXCL14's therapeutic potential for enhancing anti-tumor immunity.