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Acquired Angioedema-A Challenge in Medical Practice: A Narrative Review
Katarzyna Poznańska-Kurowska1,2, Małgorzata Skibińska1, Dorota Lorenz1
1Department of Dermatology, Pediatric Dermatology and Oncological Dermatology, Dr. W. Bieganski Regional Hospital, Kniaziewicza 1/5, 91-347 Łódź, Poland.
Journal of Clinical Medicine
|May 27, 2026
Summary
Acquired angioedema (AAE) is often secondary to other conditions, presenting a diagnostic and management challenge. Early diagnosis is crucial for preventing symptoms and identifying underlying pathologies like cancer.
Area of Science:
- Clinical immunology
- Dermatology
- Allergology
Background:
- Angioedema (AE) is a common symptom across various medical specialties.
- Hereditary angioedema (HAE) is rare; most AE cases are acquired (AAE).
- AAE is frequently secondary to underlying conditions or drug use.
Purpose of the Study:
- To review common causes of acquired angioedema.
- To discuss diagnostic approaches and pathogenesis.
- To outline potential management strategies for AAE.
Main Methods:
- Literature review focusing on acquired angioedema.
- Analysis of diagnostic challenges and etiological factors.
- Examination of current and proposed management options.
Main Results:
- AAE etiology is diverse, necessitating exclusion of serious conditions (cancers, autoimmune diseases).
- Diagnosis and management of AAE remain challenging.
- Lack of standardized prophylaxis and treatment schemes complicates AAE care.
Conclusions:
- A thorough diagnostic approach is essential for AAE.
- Identifying underlying pathologies is key for effective AAE management.
- Further research is needed for standardized AAE treatment protocols.
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