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Peripheral Artery Disease in Asian Ischaemic Stroke Patients-A Cross-Sectional Study
Narayanaswamy Venketasubramanian1
1Raffles Neuroscience Centre, Raffles Hospital, Singapore 188770, Singapore.
Neurosci
|May 27, 2026
Summary
Peripheral artery disease (PAD) affects 22% of ischemic stroke (IS) patients, particularly those with ischemic heart disease and non-lacunar infarcts. This study highlights PAD
Area of Science:
- Cardiology
- Neurology
- Vascular Medicine
Background:
- Peripheral artery disease (PAD) is a known risk factor for cardiovascular events.
- The prevalence of PAD in patients with acute ischemic stroke (IS) requires further investigation, especially in diverse Asian populations.
- Understanding the association between PAD and stroke subtypes is crucial for risk stratification.
Purpose of the Study:
- To determine the prevalence of PAD in acute IS patients in Singapore.
- To identify risk factors associated with PAD in this cohort.
- To explore the relationship between PAD, stroke classification, and carotid atherosclerosis.
Main Methods:
- A cross-sectional study involving 150 acute IS patients in Singapore.
- Data collection included demographics, vascular risk factors, and medical history.
- PAD was diagnosed using ankle-brachial index (ABI ≤0.9), and IS was classified as lacunar infarct (LI) or non-lacunar infarct (NLI) via neuroimaging. Carotid intima-medial thickening (IMT) and carotid plaques (CP) were assessed by ultrasonography.
Main Results:
- The prevalence of PAD was 22.0% (95% CI 16.1-29.3).
- PAD was significantly associated with ischemic heart disease (IHD) (aOR 5.45) and non-lacunar infarcts (NLI) (aOR 2.78) after adjusting for carotid atherosclerosis and neuroimaging findings.
- Hypercholesterolemia and older age were associated with PAD on univariate analysis but not in logistic regression.
Conclusions:
- A high prevalence of PAD exists among Asian patients with acute IS.
- PAD is independently associated with non-lacunar infarcts in IS patients.
- Screening for PAD in IS patients, especially those with IHD, may improve cardiovascular risk management.
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