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Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
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Author Correction: Atopic dermatitis.

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Three-Year Efficacy and Safety of Lebrikizumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Long-Term Extension (ADjoin).

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Related Experiment Video

Updated: May 31, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Future directions in atopic dermatitis.

Nicholas Stefanovic1, Alan D Irvine1

  • 1School of Medicine, Trinity College Dublin, Dublin, Ireland.

Journal of the American Academy of Dermatology
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis, a widespread inflammatory skin condition, still presents significant challenges despite recent advances. This review highlights key obstacles and areas ripe for innovation in managing this burdensome disease.

Keywords:
atopic dermatitiscomorbiditiesdrug developmentglobal healthprevention

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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
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Published on: September 27, 2017

Related Experiment Videos

Last Updated: May 31, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Area of Science:

  • Dermatology
  • Immunology
  • Inflammatory Diseases

Background:

  • Atopic dermatitis is a globally prevalent and burdensome inflammatory skin condition.
  • Recent years have yielded substantial insights into its epidemiology, pathogenesis, and treatment.
  • Despite progress, significant unmet needs and challenges persist in clinical management and research.

Purpose of the Study:

  • To identify and delineate the most pressing outstanding challenges in atopic dermatitis.
  • To pinpoint areas where novel innovations are most likely to impact the field.
  • To guide future research and therapeutic development for atopic dermatitis.

Main Methods:

  • Literature review and expert consensus.
  • Analysis of current research trends and clinical practice gaps.
  • Synthesis of existing knowledge to forecast future directions.

Main Results:

  • Identification of key challenges in disease understanding, diagnosis, and treatment resistance.
  • Highlighting the need for advancements in personalized medicine and targeted therapies.
  • Emphasis on the potential of emerging biotechnologies and immunomodulatory approaches.

Conclusions:

  • Addressing these challenges requires multifaceted innovative strategies.
  • Future innovations are expected in areas such as microbiome modulation, advanced diagnostics, and novel therapeutic targets.
  • Continued research and development are crucial for improving outcomes for patients with atopic dermatitis.