Irisin Improves Endometrial Receptivity in Obese Rats Through the Wnt/β-Catenin Signaling Pathway

Area of Science:

• Reproductive biology and endocrinology.
• Molecular mechanisms of endometrial receptivity.

Background:

• Obesity negatively impacts female reproductive health, including endometrial receptivity.
• The Wnt/β-catenin signaling pathway plays a crucial role in endometrial function.
• Irisin, a myokine, has potential roles in metabolic and reproductive processes.

Purpose of the Study:

• To investigate the therapeutic effects of irisin on the endometrium of obese rats.
• To explore the involvement of the Wnt/β-catenin signaling pathway in irisin's effects on endometrial receptivity.

Main Methods:

• Obese rat models were established using a high-fat diet.
• Irisin was administered intraperitoneally to obese rats.
• Pregnancy rates, blastocyst numbers, and endometrial expression of LIF, integrin αvβ3, Wnt4, and β-catenin were assessed.

Main Results:

• Obesity significantly reduced endometrial receptivity markers and Wnt/β-catenin pathway components.
• Irisin administration increased pregnancy rates and blastocyst numbers in obese rats.
• Irisin intervention upregulated the expression of LIF, integrin αvβ3, Wnt4, and β-catenin in the endometrium.

Conclusions:

• Irisin demonstrates a potential to improve endometrial receptivity in the context of obesity.
• The beneficial effects of irisin may be mediated through the modulation of the Wnt/β-catenin signaling pathway.