Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Characterisation of the Novel HLA-DRB3*01:01:27 Allele Using Third-Generation Sequencing Methods.

HLA·2026
Same author

Characterisation of the Novel HLA-DQA1*01:02:32 Allele Using Third-Generation Sequencing Methods.

HLA·2026
Same author

Third-Generation Nanopore Sequencing for Post-Transplant Chimerism Monitoring.

HLA·2026
Same author

Characterisation of the Novel HLA-A*29:198 Allele Using New Next-Generation Sequencing Methods.

HLA·2025
Same author

Characterisation of the Novel HLA-B*18:247 Allele Using New Next-Generation Sequencing Methods.

HLA·2025
Same author

Prospective Study of Recipient Human Leukocyte Antigen (HLA) Alloimmunization Following the Use of Cold-Stored Saphenous Vein Allografts in Vascular Surgery.

Journal of clinical medicine·2025

Related Experiment Video

Updated: May 31, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Characterisation of the Novel HLA-C*12:459 Allele Using Third-Generation Sequencing Methods.

Maxime Raz1, Patrice Dunoyer1, Justine Demortier1

  • 1Service de Transfusion Sanguine, Centre Hospitalier Territorial Gaston-Bourret, Nouméa, New Caledonia.

HLA
|May 29, 2026
PubMed
Summary
This summary is machine-generated.

A novel Human Leukocyte Antigen (HLA) allele, HLA-C*12:459, has been identified. This new allele is distinguished from HLA-C*12:02:02:01 by a single nucleotide substitution within the second exon.

Keywords:
HLA‐C*12:459HLANGSnew methodsnovel allele

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Genetic Variant Detection in the CALR gene using High Resolution Melting Analysis
08:46

Genetic Variant Detection in the CALR gene using High Resolution Melting Analysis

Published on: August 26, 2020

Related Experiment Videos

Last Updated: May 31, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Genetic Variant Detection in the CALR gene using High Resolution Melting Analysis
08:46

Genetic Variant Detection in the CALR gene using High Resolution Melting Analysis

Published on: August 26, 2020

Area of Science:

  • Immunogenetics
  • Molecular biology

Background:

  • Human Leukocyte Antigen (HLA) genes are highly polymorphic and crucial for immune response.
  • Accurate HLA typing is essential for transplantation and disease association studies.

Purpose of the Study:

  • To report the identification and characterization of a novel HLA-C allele.

Main Methods:

  • High-resolution HLA typing methodologies were employed.
  • Sequence analysis was performed to identify genetic variations.

Main Results:

  • A new HLA-C allele, designated HLA-C*12:459, was discovered.
  • This allele differs from the known HLA-C*12:02:02:01 by a single amino acid substitution in exon 2.

Conclusions:

  • The identification of HLA-C*12:459 expands the known HLA-C allele repertoire.
  • This finding contributes to the understanding of HLA polymorphism and may impact future immunogenetic studies.