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Related Experiment Video

Updated: Jul 2, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Characterisation of the Novel HLA-DQA1*01:02:32 Allele Using Third-Generation Sequencing Methods.

Maxime Raz1, Patrice Dunoyer1, Lea Ziller1

  • 1Service de Transfusion Sanguine, Centre Hospitalier Territorial Gaston-Bourret, Nouméa, New Caledonia.

HLA
|July 1, 2026
PubMed
Summary

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Third-Generation Nanopore Sequencing for Post-Transplant Chimerism Monitoring.

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Prospective Study of Recipient Human Leukocyte Antigen (HLA) Alloimmunization Following the Use of Cold-Stored Saphenous Vein Allografts in Vascular Surgery.

Journal of clinical medicine·2025

A novel Human Leukocyte Antigen (HLA) variant, HLA-DQA1*01:02:32, has been identified. It differs from a known variant, HLA-DQA1*01:02:01, by a single synonymous nucleotide substitution in exon 2.

Area of Science:

  • Immunogenetics
  • Molecular Biology

Background:

  • Human Leukocyte Antigen (HLA) genes are crucial for immune response.
  • Polymorphisms in HLA genes can influence immune system function and disease susceptibility.

Purpose of the Study:

  • To characterize a newly identified HLA-DQA1 allele.
  • To describe the genetic variation differentiating this new allele from a previously known one.

Main Methods:

  • Sequence analysis of the HLA-DQA1 gene.
  • Comparison of nucleotide sequences between different HLA-DQA1 alleles.

Main Results:

  • A new HLA-DQA1 allele, designated HLA-DQA1*01:02:32, was identified.
  • This allele differs from HLA-DQA1*01:02:01 by a single nucleotide change.
Keywords:
HLA‐DQA1*01:02:32HLANGSnew methodsnovel allele

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Last Updated: Jul 2, 2026

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  • The substitution is synonymous and located in exon 2 of the HLA-DQA1 gene.

    • Conclusions:

    • The discovery of HLA-DQA1*01:02:32 expands the known HLA-DQA1 allele repertoire.
    • This finding contributes to a more comprehensive understanding of HLA polymorphism.
    • Synonymous substitutions can lead to novel HLA allele identification.