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Updated: May 31, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Designed Synthesis of Unsymmetrical (Deuterated) 1,1-Diarylethylenes via Simple Sequential Coupling of Arenes and
Nicole Hanania1, Rafael Snyder1, Amit Garti1
1Institute of Chemistry, The Center for Nanoscience and Nanotechnology, and Casali Center for Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401,Israel.
Abstract:
A practical and efficient method for synthesizing unsymmetrical (deuterated) 1,1-diarylethylenes is reported. The strategy relies on simple and selective sequential coupling processes in which (1) commercially available arenes react with aldehydes to form benzhydrylphosphonium salts in a regioselective manner, (2) followed by a chemoselective Wittig-type olefination with (deuterated) formaldehyde. This approach affords (deuterated) 1,1-diarylethylenes in good yields with high levels of isotopic incorporation. This protocol provides straightforward access to versatile building blocks of interest for synthetic and medicinal applications.
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