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Updated: Jun 2, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Circular RNAs in virus-induced cancers: From mechanism to clinical implications
1Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
Abstract:
Viruses, during their lifecycle, are continuously dependent on host machinery for their survival. Sometimes this dependency leads to uncontrolled cell proliferation in the host, accounting for 12% of virus-associated cancers. Since early times, viruses have been known to produce proteins and dysregulate host proteins, but what is new to the field is the addition of a circular regulatory RNA called "circRNA". circular RNAs, due to their structure-associated stability and specificity for various cancers, are key RNA molecules for researchers seeking to understand the complex outcomes of virus-associated cancers. circRNAs can serve as both therapeutic targets and diagnostic markers due to their unique back-spliced junctions formed by back-splicing of pre-mRNA and their presence in bodily fluids. Additionally, they can be potential candidate for vaccine development. This review provides a detailed overview of how viral and host circRNAs in seven oncogenic virus-associated cancers collectively reconstruct distinct host proteins, microRNAs, and mRNAs. It discusses the discovery, biogenesis, and function of circRNAs; their roles as therapeutic targets and diagnostic markers; and the emergence of new computational and Artificial Intelligence (AI)-driven circRNA modeling.
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