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Published on: September 24, 2020

Airway Intervention in Paediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes

Saharsh Talwar1, Aryan Mahajan1, Gaurav N Pathak1

  • 1Rutgers Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
|May 31, 2026
PubMed

Insights

Airway interventions for pediatric angioedema are uncommon but significantly increase hospital stays, costs, and mortality. Racial and geographic disparities in these interventions warrant further investigation.

Area of Science:

  • Pediatric Emergency Medicine
  • Allergy and Immunology
  • Health Services Research

Background:

  • Angioedema is a potentially life-threatening condition requiring prompt medical attention.
  • Airway compromise is a major concern in pediatric angioedema cases.
  • Understanding the utilization and outcomes of airway interventions is crucial for optimizing patient care.

Purpose of the Study:

  • To characterize pediatric hospitalizations for angioedema.
  • To determine the prevalence of airway interventions in these cases.
  • To identify the outcomes and predictors associated with airway interventions.

Main Methods:

  • Cross-sectional analysis of the Kids' Inpatient Database (2003-2019).
  • Inclusion of pediatric patients (0-20 years) hospitalized with angioedema.
  • Evaluation of hospital length of stay, total charges, in-hospital mortality, and predictors of airway intervention.

Main Results:

  • 4.1% of 4238 pediatric angioedema hospitalizations involved airway procedures.
  • Airway intervention cases had longer LOS, higher charges, and increased mortality compared to non-intervention cases.
  • Black and Hispanic race were associated with higher odds of intervention; Northeast and South regions had lower odds compared to the Midwest.

Conclusions:

  • Airway interventions in pediatric angioedema are infrequent but associated with substantially higher morbidity, mortality, and healthcare costs.
  • Significant racial and geographic disparities exist in the utilization of airway interventions.
  • Further research is needed to address systemic factors influencing airway management decisions in pediatric angioedema.
Abstract

Keywords:
KIDairway interventionangioedemahealth disparitiespaediatric angioedema

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