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Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems
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Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems

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In preprints: building a resilient barrier - tissue mechanics control epithelial multilayering

Giulia Paci1

  • 1Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.

Development (Cambridge, England)
|June 2, 2026
PubMed
Abstract

No abstract available in PubMed .

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Cell-matrix's Response to Mechanical Forces01:13

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...

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