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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Visible-Light-Induced, 4CzIPN-Catalyzed Oxidative Coupling of Quinoxalin-2(1H)-ones with Aromatic Amines
Haifeng Gan1, Peipei Ma1, Hongli Wu1
1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
Abstract:
A protocol of photoinduced, 4CzIPN-catalyzed oxidative dehydrogenative coupling of quinoxalin-2(1H)-ones with aromatic amines to prepare 3-aryl-aminoquinoxalin-2(1H)-ones has been realized open to air. 3-Aryl-aminoquinoxalin-2(1H)-one derivatives were comprehensively synthesized from aromatic amines using the photocatalytic method in this article, and the reactions proceeded in moderate-to-excellent yields. This protocol can be applied to the efficient synthesis of bioactive quinoxalinone derivatives in a single step. Mechanistic investigation indicated that a radical pathway existed in the formation of the products.
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