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Characterisation of the Novel HLA-DRB1*13:374 Allele by Next-Generation Sequencing

Grégory Gatouillat1, Grégory Salez1, Marcelle Tonye-Libyh1

  • 1Laboratoire d'immunologie, CHU Reims, Reims, France.

HLA
|June 2, 2026
PubMed

Abstract:

HLA-DRB1*13:374 differs from HLA-DRB1*13:01:40 by three nucleotide substitutions located in exon 3.

Keywords:
HLA‐DRB1*13:374HLAnext‐generation sequencingnovel allele

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism

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