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Related Concept Videos

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and refractory oxide ion...
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...

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Aliasing Artifacts in Multielemental LA-ICP-TOFMS Mapping: An Old Problem Revisited.

Filip Cernatič1, Kristina Mervič2, Lukas Schlatt3

  • 1Department of Analytical Chemistry, National Institute of Chemistry, Hajdrihova ulica 19, SI-1001 Ljubljana, Slovenia.

Analytical Chemistry
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Summary

Signal aliasing in laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOFMS) is unavoidable. Optimizing acquisition time balances signal spread and data redundancy to minimize these artifacts.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Geochemistry

Background:

  • Unsynchronized laser pulses and data acquisition in quadrupole LA-ICP-MS cause signal aliasing, leading to inaccurate quantitation and degraded image quality.
  • Signal aliasing manifests as low- to medium-frequency alterations in time-averaged signals, not reflecting true analyte concentrations.

Purpose of the Study:

  • To investigate and address signal aliasing in LA-ICP-TOFMS.
  • To determine optimal acquisition time settings in TOF instruments to mitigate aliasing artifacts.

Main Methods:

  • Theoretical simulations of signal acquisition in TOF mass analyzers.
  • Experimental mapping of standard reference materials using LA-ICP-TOFMS.

Main Results:

  • Exact synchronization between laser pulses and data acquisition is impossible in LA-ICP-TOFMS due to constrained acquisition times.
  • Signal aliasing is an inherent issue in LA-ICP-TOFMS, even with acquisition times near the SPR.
  • Optimal acquisition time involves a compromise to minimize signal spread while avoiding excessive redundant data.

Conclusions:

  • Minimizing signal aliasing in LA-ICP-TOFMS requires careful selection of acquisition time.
  • A balance must be struck between reducing signal spread and managing data volume for accurate quantitative analysis and imaging.