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Three new meroterpenoids from Ferula sinkiangensis
Juan Liu1, Zhi-Wen Yue1, Si-Jia Yan2
1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, and School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
None:
Phytochemical investigation of Ferula sinkiangensis K. M. Shen led to the isolation of 12 meroterpenoids, including three new compounds (1-3) and nine known compounds (4-12). Their structures were elucidated based on comprehensive spectroscopic data, including HRESIMS and 1D, 2D NMR analyses. All compounds were assayed in vitro for protective activities against acetaminophen (APAP)-induced hepatotoxicity at 10 μM. Compounds 2-6 and 9-12 experimentally exerted protective effects against APAP-induced HepG2 cell damage.
