Study on the Alleviating Effect of Tropical Psidium guajava Basal Postbiotics on Hyperuricemia

Hyperuricemia (HUA) is a growing global health concern with a younger onset trend. Using a high-purine diet-induced HUA mouse model, this study evaluated kidney, colon, and gut microbiota damage and investigated the effects of Psidium guajava basal postbiotics (PGP). PGP reduced xanthine oxidase activity, modulated purine metabolism, and increased beneficial gut bacteria (Akkermansia muciniphila) and short-chain fatty acids (acetate, butyrate, propionate). This led to decreased blood urea nitrogen, creatinine, and renal malondialdehyde, along with reduced inflammatory factors (IL-8, LPS). Consequently, PGP alleviated HUA and mitigated HUA-induced kidney and colonic damage. This study highlights the therapeutic potential of tropical postbiotics against HUA, offering a theoretical basis for dietary supplements in chronic disease prevention.