Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Propagation of Action Potentials01:23

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Space-Time Curvature and the General Theory of Relativity01:17

Space-Time Curvature and the General Theory of Relativity

In 1905, Albert Einstein published his special theory of relativity. According to this theory, no matter in the universe can attain a speed greater than the speed of light in a vacuum, which thus serves as the speed limit of the universe.
This has been verified in many experiments. However, space and time are no longer absolute. Two observers moving relative to one another do not agree on the length of objects or the passage of time. The mechanics of objects based on Newton's laws of motion,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychedelics disrupt hierarchical cortical propagations in the default mode network of humans and mice.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Causal and directional elements of global brain dynamics.

bioRxiv : the preprint server for biology·2026
Same author

A 3D-Printed Scaffolded Hydrogel Microneedle Array Biosensor for Real-Time, Continuous Monitoring.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Direct Cardiac Reprogramming in the Omics Era: Advances, Mechanisms, and Applications.

Cellular reprogramming·2026
Same author

Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.

bioRxiv : the preprint server for biology·2025
Same author

Quantum critical electro-optic and piezo-electric nonlinearities.

Science (New York, N.Y.)·2025
Same journal

Complex Indel Detection: A Simulation-Based Framework and Parsing with FreeBayes.

bioRxiv : the preprint server for biology·2026
Same journal

Emulating the gingival-tooth interface during bacterial, fungal, and viral infection in a microphysiological model of the human oral cavity.

bioRxiv : the preprint server for biology·2026
Same journal

Local SNP-explained methylation variation reveals genetically anchored and exposure-associated methylation architecture in the human brain.

bioRxiv : the preprint server for biology·2026
Same journal

Perinatal Semaglutide Treatment Improves Maternal Health and Mitigates Offspring Metabolic Dysfunction in a Mouse Model of Maternal Obesity.

bioRxiv : the preprint server for biology·2026
Same journal

Pervasive cryptic selection in the human noncoding genome.

bioRxiv : the preprint server for biology·2026
Same journal

Secreted ORF8 reprograms macrophages to enhance SARS-CoV-2 infection of lung epithelial cells.

bioRxiv : the preprint server for biology·2026
See all related articles
  1. Home
  3. Intrinsic Space-time Couplings Governing Multi-scale Cortical Dynamics.
  1. Home
  3. Intrinsic Space-time Couplings Governing Multi-scale Cortical Dynamics.

Related Experiment Video

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Intrinsic space-time couplings governing multi-scale cortical dynamics.

Alexander D White, Yu Wang, John Kochalka

    Biorxiv : the Preprint Server for Biology
    |June 5, 2026

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Researchers developed conformal immersion microscopy to track brain activity across the entire neocortex. This new method reveals fundamental dynamical elements governing brain organization, aiding neuromodulation research.

    More Related Videos

    In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
    06:18

    In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution

    Published on: November 21, 2023

    Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
    08:51

    Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

    Published on: November 1, 2019

    Related Experiment Videos

    Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
    07:52

    Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

    Published on: May 23, 2025

    In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
    06:18

    In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution

    Published on: November 21, 2023

    Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
    08:51

    Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

    Published on: November 1, 2019

    Area of Science:

    • Neuroscience
    • Biophysics
    • Systems Neuroscience

    Background:

    • The neocortex is a key target for neuromodulation, but its global operational principles remain elusive.
    • Existing technologies struggle to simultaneously capture cortex-wide activity and millisecond neuronal firing resolution.

    Purpose of the Study:

    • To introduce and apply a novel microscopy technique for high-resolution, large-scale brain activity tracking.
    • To identify fundamental principles governing neocortical dynamics and organization.

    Main Methods:

    • Conformal immersion microscopy enabling cortex-wide activity tracking with millisecond temporal and 100 μm spatial resolution.
    • Multiscale analysis applying physics-based frameworks to neural activity data.
    • Perturbation studies using pharmacological, optogenetic, and genetic interventions.

    Main Results:

    • Identified a fundamental frequency-dependent coherence length partitioning the neocortex into discrete dynamical elements.
    • Demonstrated conserved dynamics across sub-threshold and suprathreshold neural activity regimes.
    • Showed robustness of these dynamical elements to various interventions, with conditions for overriding boundaries.

    Conclusions:

    • Conformal immersion microscopy provides unprecedented spatiotemporal resolution for neocortical dynamics.
    • Fundamental dynamical elements and their scale-invariant properties govern neocortical organization.
    • Findings offer a foundation for mechanistically informed basic and translational neuromodulation research.