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Panel-negative strategy for suspected fusion-driven papillary thyroid carcinoma
Yoichiro Okubo1, Ikki Takada2, Mei Kadoya3
1Kanagawa Cancer Center, Department of Pathology, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan. yoichiro0207@hotmail.com.
Molecular testing for thyroid nodules and papillary thyroid carcinoma (PTC) is crucial when results impact treatment. A new framework helps interpret limited test results, especially when suspicion for fusion-driven PTC persists, ensuring appropriate molecular testing.
Area of Science:
- Oncology
- Molecular Diagnostics
- Genetics
Background:
- Molecular testing for thyroid nodules and papillary thyroid carcinoma (PTC) is vital for treatment decisions.
- Limited assays may not detect clinically relevant fusions, leading to potential misinterpretation.
- Existing workflows may not adequately address fusion detection in PTC.
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