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Preparation of a chloride salt of covalently modified isoniazid
Rolivhuwa Mahwasane1, Mark G Smith1
1University of South Africa, Chemistry Department, Unisa Science Campus, 28 Pioneer Avenue, Florida, Roodepoort, Gauteng, South Africa.
Abstract:
A novel covalently modified isoniazid salt {4-[N'-(propan-2-yl-idene)hydrazinecarbon-yl]pyridin-1-ium chloride}, C9H12N3O+·Cl-, was synthesized using a slow diffusion layering technique under ambient conditions. Single-crystal X-ray diffraction (SC-XRD) analysis revealed that the compound crystallizes in the triclinic space group P1. The crystal structure features prominent N-H⋯Cl hydrogen bonds, indicating strong inter-molecular inter-actions between the chloride ion and the modified isoniazid framework.
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