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Granular Cell Tumor: A Rare Suprasellar Tumor
Augusto Dextre-Espinoza1, Sofia Ildefonso-Najarro1, Fiorella Beatriz Gonzales Chiroque1
1Servicio de Endocrinología del Hospital Nacional Guillermo Almenara Irigoyen, Lima, Perú.
Introduction:
Granular cell tumors of the neurohypophysis are rare, benign neoplasms originating from pituicytes that often pose diagnostic challenges due to their resemblance to other sellar lesions.
Case Presentation:
We report the case of a 26-year-old man with a 2-year history of headache, polyuria, and hypopituitarism. Magnetic resonance imaging revealed a 21 × 23×30 mm suprasellar mass compressing the optic chiasm and hypothalamus. Hormonal evaluation showed hypogonadotropic hypogonadism, central hypothyroidism, and arginine vasopressin deficiency. The patient underwent partial tumor resection. Histopathology confirmed a grade I granular cell tumor, positive for thyroid transcription factor 1, S100, and vimentin.
Discussion:
Granular cell tumors are slow-growing lesions with nonspecific clinical and radiologic features. Diagnosis relies on histologic and immunohistochemical findings. Complete resection is often limited by tumor vascularity and proximity to vital structures.
Conclusions:
Granular cell tumors should be considered in the differential diagnosis of suprasellar tumors. Early recognition and multidisciplinary management may improve patient outcomes.
