Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peptide Identification Using Tandem Mass Spectrometry

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DDT exposure drives time-dependent restructuring of soil microbiomes in urban garden microcosms.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes·2026

Same author

Metagenome-assembled genomes from urban pigeon feces in Istanbul, Türkiye.

Microbiology resource announcements·2026

Same author

MetaPepticon: automated prediction of anticancer peptides from microbial genomes and metagenomes.

PeerJ·2026

Same author

Biotechnological Applications of Archaea.

Progress in molecular and subcellular biology·2026

Same author

Microbial Omics.

Progress in molecular and subcellular biology·2026

Same author

Construction of Protein Sequence Databases for Metaproteomics: A Review of the Current Tools and Databases.

Journal of proteome research·2024

Same journal

Dataset of Optimized Structures of Aliphatic Chains Chemisorbed on Si(110) and Si(111) Surfaces via First-Principles Methods.

Scientific data·2026

Same journal

EURO-PROBE - Manual segmentations of the prostate and intraprostatic urethra on T2-weighted MRI.

Scientific data·2026

Same journal

Chromosome-Level Genome Assembly of Southern Africa Mozambique Tilapia (Oreochromis mossambicus) using PacBio HiFi and Omni-C sequencing.

Scientific data·2026

Same journal

Ovarian Stainology: Database of evidence-based immunohistochemical antigen expression in ovarian tumors.

Scientific data·2026

Same journal

A dataset of small protein conformational ensembles from all-atom molecular dynamics simulations.

Scientific data·2026

Same journal

A real-world Fitbit-derived dataset of activity, sleep, and heart rate with matched clinical factors in on-treatment lung cancer patients.

Scientific data·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Dual Activity Microbial Peptides Catalog.

Özlem Sağıroğlu^1,2, Muzaffer Arıkan³

¹Program of Biotechnology, Department of Biology, Institute of Graduate Studies in Sciences, Istanbul University, Istanbul, 34134, Türkiye.

Scientific Data

|June 8, 2026

Summary

This summary is machine-generated.

Researchers identified dual-activity antimicrobial peptides (AMPs) and anticancer peptides (ACPs) from microbial sources. The Dual Activity Microbial Peptides Catalog (DAMPC) offers a new resource for these promising therapeutic agents.

More Related Videos

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Published on: December 6, 2017

Related Experiment Videos

Last Updated: Jun 10, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates

Published on: December 6, 2017

Area of Science:

Microbiology
Biochemistry
Computational Biology

Background:

Antibiotic resistance and cancer are critical global health threats.
Antimicrobial peptides (AMPs) show promise as alternatives to antibiotics.
Some AMPs also possess anticancer peptide (ACP) activity, offering dual therapeutic potential.

Purpose of the Study:

To identify microbial peptides with dual antimicrobial and anticancer activity.
To address the underrepresentation of ACPs in databases by exploring microbial sources.
To create a curated catalog of these dual-activity peptides.

Main Methods:

Utilized a consensus strategy with three ACP and two AMP prediction tools.
Screened over 124 million microbial small open reading frames (smORFs).
Filtered for non-toxic peptides exhibiting dual activity.

Main Results:

Identified 40,251 non-toxic microbial peptides with dual AMP and ACP properties.
Compiled these findings into the Dual Activity Microbial Peptides Catalog (DAMPC).
DAMPC is a searchable resource for dual-activity, non-toxic microbial peptide sequences.

Conclusions:

Microbial sources harbor a significant number of peptides with dual antimicrobial and anticancer activities.
The DAMPC provides a valuable resource for further research and development of novel therapeutics.
This catalog facilitates the exploration of microbial peptides for combating antibiotic resistance and cancer.