Related Experiment Video
Updated: Jun 10, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
Published on: June 9, 2023
Deciphering the PI3K-AKT-mTOR Signalling Pathway in Cancer: A Mechanistic Insight
Chetana C Galav1, Somali Sanyal2, Sukriti Singh2
1Department of Biotechnology, Chhatrapati Shivaji Maharaj University, Maharashtra, India.
None:
The PI3K-AKT-mTOR signalling pathway plays a central role in regulating cell growth, survival, and proliferation, significantly influencing the development and progression of cancer. This review examines the mechanistic and structural complexities of the major components of the PI3K-AKT-mTOR pathway, exploring their potential as therapeutic targets in cancer. Aberrant activation of this signalling pathway has been strongly linked to the initiation and progression of various cancers, including breast, ovarian, gastric, lung, prostate, endometrial, laryngeal, and hepatocellular carcinoma, among others. The review highlights current therapeutic strategies that aim to inhibit PI3K, AKT, and mTOR in cancer treatment, emphasising the use of small-molecule inhibitors and monoclonal antibodies. Additionally, it discusses the promise of combination therapies in enhancing treatment effectiveness and addressing resistance mechanisms that may arise during pathway inhibition. Understanding these resistance mechanisms and developing novel strategies to overcome them are critical for improving therapeutic outcomes for cancer patients. Overall, this study provides a thorough examination of the PI3K-AKT-mTOR pathway, its potential for therapeutic intervention, and the evolving trends in cancer treatment, offering valuable insights for both researchers and clinicians.
Related Concept Videos
PI3K/mTOR/AKT Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
The JAK-STAT Signaling Pathway
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
