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Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
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Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...

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Related Experiment Video

Updated: Jun 10, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

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Published on: May 7, 2014

Differences in functional connectivity during midlife between menopause stages.

Abigail A Testo1, Julie A Dumas

  • 1Department of Psychiatry, Larner College of Medicine, The University of Vermont, Burlington, VT.

Menopause (New York, N.Y.)
|June 9, 2026
PubMed
Summary
This summary is machine-generated.

Menopause stage impacts brain connectivity in midlife women. Resting-state functional connectivity differences were observed between pre-, peri-, and postmenopausal groups, particularly in specific brain regions.

Keywords:
Functional connectivityMenopauseMidlifefMRI

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Published on: February 14, 2014

Area of Science:

  • Neuroscience
  • Aging Research
  • Women's Health

Background:

  • Menopause is a significant biological transition in midlife women.
  • Brain function changes can occur during aging.
  • Understanding these changes is crucial for women's health.

Purpose of the Study:

  • To investigate the relationship between menopause stages and brain's resting-state functional connectivity.
  • To identify specific brain regions affected by menopausal transition.

Main Methods:

  • Utilized data from the Human Connectome Project-Aging 2.0 release.
  • Included imaging and demographic data from 151 female participants (40-55 years).
  • Assessed resting-state functional connectivity using Conn Toolbox at connection and cluster levels.

Main Results:

  • Identified differences in resting-state functional connectivity between pre-, peri-, and postmenopausal groups.
  • Found altered connectivity in the supramarginal gyrus and planum temporale.
  • Observed lower connectivity in postmenopausal women compared to premenopausal women in specific brain regions.

Conclusions:

  • Resting-state functional connectivity varies across menopause stages.
  • The menopause transition is linked to alterations in brain functioning during midlife.
  • These findings highlight the relevance of menopause to female brain aging.