Related Experiment Video
Updated: Jun 11, 2026
Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
Microfragmented Adipose Tissue (MFAT) Injection for Refractory Generator Pocket Pain (GPP) in Spinal Cord Stimulation
Patrizia Vendramin1, Alvise Martini1, Eleonora Bonora1
1Department of Anesthesia, Intensive Care and Pain Therapy, Verona University Hospital, Verona, Italy.
Background:
Generator pocket pain (GPP) may develop in spinal cord stimulation (SCS) patients, with a frequency ranging from 0.9% to 64%. While several treatments have been proposed, the only available options for SCS patients experiencing refractory pain are implantable pulse generator (IPG) relocation or removal.
Case Report:
We treated a 62-year-old man with late-onset refractory GPP using the autologous microfragmented adipose tissue (MFAT) injection into the IPG pocket. A total of 30 mL of MFAT harvested from abdominal fat was injected. The procedure was well tolerated, with no adverse events. The patient reported a significant reduction in pain intensity immediately after the injection, with his visual analog scale (VAS) score decreasing from 80 to 20/100. At the third-month follow-up, he continued to experience the same level of pain relief.
Conclusion:
The autologous MFAT injection in refractory GPP patients is a promising salvage option. However, additional cases will be needed to better evaluate the efficacy and long-term outcomes of this treatment.
More Related Videos
04:42Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
Published on: June 26, 2018
08:20Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model
Published on: June 30, 2023