Related Experiment Video
Updated: Jun 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Molecularly Guided Therapy in Hepatobiliary Cancers: Current Standards and Emerging Horizons
Jorge Adeva1, Valerie S Kalluri2, Fen Saj3
1Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
None:
Hepatobiliary malignancies constitute a major global oncologic burden, encompassing a heterogeneous spectrum of tumors comprised of hepatocellular carcinoma (HCC) and biliary tract cancers (BTC). While precision oncology has transformed BTC management-particularly intrahepatic cholangiocarcinoma, where molecular profiling identifies actionable alterations in FGFR2, IDH1, HER2, and other targetable pathways. The contemporary therapeutic landscape integrates targeted agents with immune checkpoint inhibitors; yet, optimal treatment sequencing and biomarker-driven patient selection require further refinement. This review synthesizes current evidence-based approaches and emerging therapeutic paradigms in hepatobiliary oncology, examining how molecular characterization can bridge the precision medicine gap between BTC and HCC to improve patient outcomes.
More Related Videos
09:11Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistant Cancers
Treatment Resistent Cancers