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Updated: Jun 13, 2026
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Clinical Imaging of Microwave Mammography
Published on: November 14, 2025
Distinguishing Malignant from Benign Causes of Breast Size Changes: A Case-based Primer for the Radiologist
Aurela I Clark1, Hannah Conley1, Wendi A Owen1
1Department of Radiology, University of Kentucky College of Medicine, 800 Rose St, Rm HX 318, Lexington, KY 40536.
Summary
Breast size changes, unilateral or bilateral, require careful evaluation. Distinguishing benign from malignant causes is crucial for effective patient management and diagnosis.
Area of Science:
- Radiology
- Oncology
- Breast Imaging
Background:
- Breast size alterations are common clinical concerns.
- Unilateral changes may indicate malignancy, necessitating prompt diagnosis.
- Bilateral changes are often linked to benign conditions.
Purpose of the Study:
- To review the evaluation and management of breast size changes.
- To provide a diagnostic framework integrating clinical and imaging data.
- To aid radiologists and clinicians in differentiating malignant from benign causes.
Main Methods:
- Review of clinical scenarios and associated conditions.
- Integration of clinical history, physical examination, and imaging findings.
- Exploration of prior imaging, clinical context, and multimodality imaging.
Main Results:
- A structured diagnostic approach is essential for accurate assessment.
- Multimodality imaging aids in identifying underlying causes.
- Synthesis of clinical and imaging data guides decision-making.
Conclusions:
- Radiologists play a key role in diagnosing breast size changes.
- Accurate diagnosis is vital for appropriate patient care and anxiety reduction.
- A practical framework assists in managing diverse breast conditions.
