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RARE CLINICAL CASE OF CHORIOCARCINOMA WITH MULTIPLE METASTASES AND A FAVORABLE OUTCOME: DIAGNOSTIC CHALLENGES
S Lutvinov1, O Malinina1, O Taran1
1Vinnytsia National Pyrogov memorial Medical University, Department of Obstetrics and Gynecology N1.
Georgian Medical News
|June 14, 2026
Summary
Early diagnosis of gestational trophoblastic neoplasia (GTN) is challenging due to atypical presentations. Regular monitoring and prompt verification are crucial for managing aggressive choriocarcinoma and preventing metastasis.
Area of Science:
- Gynecology
- Oncology
- Pathology
Background:
- Gestational trophoblastic neoplasia (GTN) affects approximately 110-120 per 100,000 pregnancies.
- Choriocarcinoma, a malignant GTN subtype, presents aggressive behavior and rapid metastasis.
- This case highlights diagnostic challenges of GTN post-pregnancy termination.
Purpose of the Study:
- Describe a rare choriocarcinoma case with multiple metastases and favorable outcome.
- Evaluate treatment effectiveness for advanced GTN.
- Analyze factors impacting GTN diagnosis accuracy and timeliness.
Main Methods:
- Clinical case analysis of malignant gestational trophoblastic neoplasia.
- Comprehensive examination: β-hCG (ECLIA), blood tests, ultrasound, CT.
- Histological examination and FIGO staging.
Main Results:
- Atypical clinical and ultrasound findings complicated early GTN diagnosis.
- Delayed verification led to advanced choriocarcinoma with metastases.
- Effective treatment achieved sustained remission in an advanced case.
Conclusions:
- Atypical GTN presentations and non-standard β-hCG dynamics impede early diagnosis.
- Lack of regular monitoring and morphological confirmation increases risk of advanced disease.
- Multimodal therapy (surgery, chemotherapy, radiation) is effective for choriocarcinoma, even at advanced stages.
