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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...

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Next-Generation Sequencing for Minimal Residual Disease Detection in Pediatric Acute Lymphoblastic Leukemia: Technological Advances, Clinical Translations and Current Challenges.

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Identification of the HLA-DRB5*01:15 Allele in a Chinese Individual.

Fenfen Jin1, Fenying Zhao1, Haipin Chen1

  • 1Department of Hematology-Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, People's Republic of China.

HLA
|June 16, 2026
PubMed
Summary
This summary is machine-generated.

The human leukocyte antigen (HLA) DRB5*01:15 gene variant differs from DRB5*01:01:01:02 by specific genetic alterations. These changes involve both coding and non-coding regions of the gene.

Keywords:
HLA‐DRB5*01:15HLA typinglong read sequencing

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Area of Science:

  • Immunogenetics
  • Molecular Biology

Background:

  • The human leukocyte antigen (HLA) system plays a critical role in immune response.
  • Specific HLA gene variants can influence disease susceptibility and drug efficacy.

Purpose of the Study:

  • To characterize the genetic differences between HLA-DRB5*01:15 and HLA-DRB5*01:01:01:02.

Main Methods:

  • Comparative sequence analysis of the HLA-DRB5 gene.
  • Identification of nucleotide and amino acid variations.

Main Results:

  • HLA-DRB5*01:15 exhibits one non-synonymous substitution in exon 2 compared to DRB5*01:01:01:02.
  • A single nucleotide substitution was identified in intron 1 of HLA-DRB5*01:15.

Conclusions:

  • The identified genetic variations distinguish HLA-DRB5*01:15 from DRB5*01:01:01:02.
  • These molecular differences may have implications for immune function and serological typing.