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Updated: Jun 17, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
An endoplasmic reticulum-directed ROS burst strategy powered by H2O2 abundance for chemodynamic/immuno tumor therapy
Ruixiang Liu1, Shurui Weng1, Jiayi Liu1
1College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China. conghuiliu@szu.edu.cn.
Abstract:
The endoplasmic reticulum (ER), enriched with H2O2, offers an ideal subcellular site to overcome the limited intracellular H2O2 supply in conventional chemodynamic therapy. By developing an ER-targeted chemodynamic nanoplatform, localized ROS bursts induce ER stress and immunogenic cell death, thereby amplifying antitumor immune activation and enabling a chemodynamic-immunotherapeutic strategy.
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