SREBP gene polymorphisms and ambulatory blood pressure parameters in Chinese adolescents: a cross-sectional study

The purpose of this study was to investigate the association between SREBP gene polymorphisms and ambulatory blood pressure phenotypes. In the present study, 514 college students from a university in China were recruited. Questionnaire surveys, physical examinations, ambulatory blood pressure monitoring, and blood samples were collected. The relationship between SREBP gene polymorphisms and ambulatory blood pressure parameters in college students was analyzed using a multivariable linear regression model. A total of 510 students with complete data were included in the final analysis. After adjustment for sex, age, weight status, ethnicity, monthly household income per capita, salt intake habits, fruit intake frequency, vegetable intake frequency, smoking, alcohol consumption, history of hypertension, and waist circumference, SREBP1/rs11868035 was associated with 24-h SBP levels in college students under the additive and recessive genetic models (additive: β = 1.39, P = 0.045; recessive: β = 1.75, P = 0.027), but results were not significant after Bonferroni correction (P > 0.0167). Under the recessive genetic model, SREBP1/rs11868035 was associated with daytime SBP levels (β = 1.97, P = 0.026), and SREBP2/rs2228314 was positively associated with daytime DBP levels in college students (β = 2.44, P = 0.033), but neither remained significant after Bonferroni correction (P > 0.0167).

SREBP gene polymorphisms exhibited suggestive associations with ambulatory blood pressure in Chinese adolescents. Although the associations were not significant after multiple testing correction, these findings suggest potential genetic influences on blood pressure regulation in youth and may inform future research on genetically informed approaches to hypertension prevention.

• Accumulating evidence has demonstrated associations between SREBP gene polymorphisms and cardiometabolic phenotypes. • To date, no studies have investigated the association between SREBP gene polymorphisms and ambulatory blood pressure phenotypes.

• In this exploratory analysis, we identified an association between the rs11868035 polymorphism in the SREBP1 gene and ambulatory blood pressure phenotypes, including 24-h and daytime systolic blood pressure, among Chinese adolescents. • The SREBP1/rs11868035 polymorphism appears to be associated with higher 24-h and daytime systolic blood pressure, whereas the SREBP2/rs2228314 polymorphism was positively associated with daytime diastolic blood pressure.