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Published on: April 30, 2018
Development of a High-Throughput Experimentation Workflow for Photochemical Reaction Screening
Nam Nguyen1, Colin Masui1, Adam Childs1
1Synthetic Molecule Analytical Chemistry, Synthetic Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
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Commercially available lab equipment was successfully integrated to enable visible-range photochemistry in a high-throughput 96-well screening format with magnetic stirring. Precise temperature control with maximal throughput was achieved by positioning the light source above the reaction mixtures and a cooling source below. This platform was benchmarked against other state-of-the-art commercial options using the Doyle-MacMillan reaction. Establishing a highly irradiated, temperature-controlled micromole-scale high-throughput experimentation (HTE) reaction screening protocol in a standard 96-well format could potentially accelerate modern reaction optimization in both medicinal and process chemistry.

