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Related Experiment Video

Updated: Jun 18, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

Audiogram Configuration Predicts Treatment Response in Sudden Sensorineural Hearing Loss.

Li Guo1,2, Junli Wang1,2, Ying Gao1,2

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|June 17, 2026
PubMed
Summary

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The initial pure tone audiogram configuration significantly predicts recovery from sudden hearing loss. Ascending and flat patterns indicate a better prognosis than descending or total-deaf patterns.

Area of Science:

  • Audiology
  • Otolaryngology
  • Epidemiology

Background:

  • Sudden sensorineural hearing loss (ISSNHL) is a medical emergency requiring prompt diagnosis and treatment.
  • Prognostic factors for recovery in ISSNHL are crucial for guiding clinical decisions and patient counseling.
  • The predictive value of initial audiogram configuration for ISSNHL recovery remains incompletely understood.

Purpose of the Study:

  • To evaluate if the initial pure tone audiogram configuration (ascending, descending, flat, or total-deaf) predicts complete recovery in unilateral ISSNHL.
  • To assess the utility of audiogram configuration as a component in developing prognostic models for ISSNHL.

Main Methods:

  • Retrospective cohort study involving adults with unilateral ISSNHL treated at a single tertiary care center.
Keywords:
audiogram configurationhearing recoveryprognosissudden sensorineural hearing losstreatment response

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  • Patients were categorized based on their initial audiogram configuration.
  • Multivariable logistic regression analysis was employed to identify independent predictors of complete recovery, with model performance assessed using AUC and Nagelkerke R².

    • Main Results:

    • Of 487 patients, 16.4% achieved complete recovery. Recovery rates varied significantly by audiogram configuration: 50.0% for ascending, 25.2% for flat, 9.8% for descending, and 0% for total-deaf.
    • Descending (OR 0.25) and total-deaf (OR 0.05) configurations were independent predictors of worse outcomes.
    • Higher initial pure tone average (PTA) and older age also negatively predicted recovery. The model achieved an AUC of 0.78 and Nagelkerke R² of 0.32.

    Conclusions:

    • Initial audiogram configuration is a significant independent prognostic marker for recovery in ISSNHL.
    • Ascending and flat audiogram patterns are associated with a better prognosis compared to descending and total-deaf patterns.
    • These audiogram classifications should be incorporated into clinical risk stratification and future predictive models for ISSNHL.