Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New in vitro dissolution test apparatus.

S S Nasir, L O Wilken, S M Nasir

    Journal of Pharmaceutical Sciences
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Immobilized rhodanese: some aspects of anion inhibition kinetics and modulation by cations.

    Journal of biochemical toxicology·1993
    Same author

    Adherence to pharmacotherapeutic regimen. Assessment and intervention.

    The Alabama journal of medical sciences·1988
    Same author

    The effects of autoclaving on the stability of physostigmine salicylate in buffer solutions.

    Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1988
    Same author

    The effects of withdrawal and duration of storage on the sterility of multiple dose vials.

    Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1987
    Same author

    Liquid chromatographic determination of the pH-dependent degradation of eseroline--hydrolysis product of physostigmine.

    Journal of pharmaceutical and biomedical analysis·1987
    Same author

    Effects of gentamicin solution and cream on the healing of open wounds.

    American journal of veterinary research·1984
    Same journal

    Immune tolerance platforms to mitigate unwanted immune responses.

    Journal of pharmaceutical sciences·2026
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    See all related articles

    A novel in vitro dissolution apparatus was developed. This device effectively measures drug release from solid dosage forms, showing potential for correlating with in vivo bioavailability by controlling air pressure.

    Area of Science:

    • Pharmaceutical Sciences
    • Drug Delivery Systems
    • Biopharmaceutics

    Background:

    • Accurate in vitro dissolution testing is crucial for predicting in vivo drug performance.
    • Existing methods like the Levy beaker and USP apparatus have limitations in controlling dissolution parameters.
    • Developing novel apparatus for controlled drug release studies is essential.

    Purpose of the Study:

    • To design and evaluate a new in vitro dissolution test apparatus.
    • To assess the apparatus's ability to measure drug release rates from solid dosage forms.
    • To explore the potential correlation between dissolution data from the new apparatus and in vivo bioavailability.

    Main Methods:

    • A new in vitro dissolution test apparatus was designed.
    • Compressed tablets with varying drug solubility characteristics were tested.

    Related Experiment Videos

  • Dissolution patterns were compared against Levy beaker and USP methods under different air pressures.
  • The optimal air pressure for tablet dissolution was determined.

    • Main Results:

    • The new apparatus demonstrated effective measurement of drug dissolution rates.
    • An air pressure of 46 mm was found suitable for determining tablet dissolution.
    • The apparatus showed no excessive particle settling or screen clogging.
    • Controlled drug release was achieved by adjusting air pressure.

    Conclusions:

    • The designed in vitro dissolution tester is a promising tool for drug release assessment.
    • The apparatus facilitates easy control of dissolution rate via air pressure adjustment.
    • This device has the potential to correlate in vitro dissolution with in vivo bioavailability.
    • The apparatus offers advantages such as consistent performance and ease of use.