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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Biocompatibility With Osteogenic Potential of Premixed Bioceramic Cements for Use in Apical Surgery
Yesol Kim1, Jae-Hoon Kim2, Unni Krishnan3
1Department of Conservative Dentistry, School of Dentistry, Dental Research Institute, Dental and Life Science Institute, Pusan National University, Yangsan, Korea.
Summary
Premixed bioceramic cements (PBCs) show excellent biocompatibility and osteogenic potential, making them suitable alternatives to mineral trioxide aggregate (MTA) for endodontic microsurgery. These materials support cell viability and bone formation, indicating promising clinical applications.
Area of Science:
- Biomaterials Science
- Endodontics
- Regenerative Dentistry
Background:
- Mineral trioxide aggregate (MTA) is a standard for endodontic retrograde fillings.
- Biocompatible and osteogenic alternatives are needed for improved clinical outcomes.
- Premixed bioceramic cements (PBCs) offer potential advantages in handling and properties.
Purpose of the Study:
- To evaluate the biocompatibility and osteogenic potential of four PBCs.
- To compare PBCs as alternatives to MTA in endodontic microsurgery.
- To assess setting times in different media.
Main Methods:
- Cytocompatibility assessed via MTT assays on human periodontal ligament fibroblasts.
- Osteogenic differentiation evaluated by alkaline phosphatase activity and Alizarin Red S staining.
- Setting times measured in saline and fetal bovine serum (FBS).
Main Results:
- All tested PBCs demonstrated over 90% cell viability.
- CeraPutty exhibited significantly higher alkaline phosphatase activity, indicating enhanced early osteogenic differentiation.
- All materials promoted mineral deposition, and setting times varied by material and medium.
Conclusions:
- PBCs exhibit favorable biological and setting properties for endodontic applications.
- These materials demonstrate significant biocompatibility and osteogenic potential.
- PBCs are reliable alternatives to MTA for retrograde filling in endodontic microsurgery.
