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Related Experiment Video

Updated: Jun 21, 2026

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine
05:56

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine

Published on: October 27, 2023

Chronic Stress Predictability Modulates the Severity of Apical Periodontitis Induced in Wistar Rats.

Giovanna Bignoto Minhoto1, Gustavo G Guerrero1, Rayana D Khoury1

  • 1Department of Restorative Dentistry, Endodontic Division, São Paulo State University - UNESP, Institute of Science and Technology, São Paulo, Brazil.

International Endodontic Journal
|June 20, 2026
PubMed
Summary

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This summary is machine-generated.

Unpredictable chronic stress worsened periapical lesions in rats. Stress predictability influences the progression of apical periodontitis, highlighting its role in disease severity.

Area of Science:

  • Endodontics
  • Stress Research
  • Oral Pathology

Background:

  • Apical periodontitis is a common inflammatory disease.
  • Chronic stress is linked to various health issues.
  • The impact of stress predictability on apical periodontitis is not well understood.

Purpose of the Study:

  • To investigate how predictable and unpredictable chronic stress affect periapical lesion development and severity.
  • To determine if stress predictability modulates apical periodontitis progression.

Main Methods:

  • Wistar rats were divided into control and three experimental groups: apical periodontitis without stress, with predictable stress, and with unpredictable stress.
  • Stress was applied for 42 days; apical periodontitis was induced on day 21.
Keywords:
animal modelapical periodontitisbone losschronic stressendodontics

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  • Lesion severity was assessed using microcomputed tomography and histological analysis after behavioral confirmation of stress.

    • Main Results:

    • Behavioral tests confirmed successful stress induction in both stressed groups.
    • Unpredictable stress led to significantly larger periapical lesions and higher inflammation compared to predictable stress or no stress.
    • Microcomputed tomography and histological analyses confirmed greater disease severity in the unpredictable stress group.

    Conclusions:

    • Unpredictable chronic stress significantly exacerbates the development and severity of periapical lesions.
    • Stress predictability appears to be a crucial factor modulating apical periodontitis progression.