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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

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Related Experiment Video

Updated: Jun 23, 2026

Dot Blot Assay for Detecting Global N6-Methyladenosine RNA Modification Levels
08:40

Dot Blot Assay for Detecting Global N6-Methyladenosine RNA Modification Levels

Published on: February 6, 2026

m6A-FORM: An m6A-focused Foundation Model for Decoding m6A Regulatory Function.

Ting-He Zhang, Sumin Jo, Shou-Jiang Gao

    Arxiv
    |June 22, 2026
    PubMed
    Summary
    This summary is machine-generated.

    N6-methyladenosine (m6A) is crucial for mRNA regulation. A new foundation model, m6A-FORM, deciphers m6A

    More Related Videos

    A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
    08:56

    A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

    Published on: December 5, 2016

    Related Experiment Videos

    Last Updated: Jun 23, 2026

    Dot Blot Assay for Detecting Global N6-Methyladenosine RNA Modification Levels
    08:40

    Dot Blot Assay for Detecting Global N6-Methyladenosine RNA Modification Levels

    Published on: February 6, 2026

    A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
    08:56

    A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

    Published on: December 5, 2016

    Area of Science:

    • Epitranscriptomics
    • Computational Biology
    • Genomics

    Background:

    • N6-methyladenosine (m6A) is a key RNA modification influencing mRNA fate, stability, and decay.
    • Current computational methods primarily predict m6A sites, lacking comprehensive analysis of regulatory context and function.
    • Understanding m6A's role requires advanced tools to interpret epitranscriptomic profiles.

    Purpose of the Study:

    • To introduce m6A-FORM, a foundation model designed for m6A regulatory discovery.
    • To develop a model capable of inferring m6A regulatory context and function from epitranscriptomic data.
    • To enable prediction of m6A reader/writer/eraser binding and RNA decay.

    Main Methods:

    • Development and pretraining of m6A-FORM on a large dataset (24.9 million RNA windows, 22.5 million MeRIP-seq regions) from 143 human studies.
    • Adaptation of the m6A-FORM encoder for specific tasks: m6A site discovery, regulator binding prediction, YTHDF2-mediated decay prediction, and tissue-scale mapping.
    • Application of the model to 67 datasets across 24 human tissues.

    Main Results:

    • m6A-FORM successfully predicts the binding of 19 m6A readers, writers, and erasers.
    • Identified sequence and RNA-binding protein (RBP) context features linked to YTHDF2-mediated RNA degradation.
    • Discovered tissue-conserved m6A sites associated with enhanced methylation, reader binding, RBP occupancy, and decay propensity.

    Conclusions:

    • m6A-FORM provides a powerful framework for discovering m6A regulatory mechanisms and functions.
    • The model advances the interpretation of epitranscriptomic profiles for a deeper understanding of RNA regulation.
    • Tissue-specific m6A patterns and their functional implications can be elucidated using m6A-FORM.