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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Antibiotic resistance: and now what?
Francisco Nacinovich1,2, Waldo Belloso3,2, Yanina Nuccetelli4,2
1Instituto Cardiovascular de Buenos Aires, Argentina.
Abstract:
Antimicrobial resistance (AMR) represents a global threat that affects all populations and ecosystems equally, partly driven by the massive and improper use of antibiotics since their discovery in the 20th century. While microorganisms' ability to develop resistance is a natural adaptation mechanism, human practices have dramatically accelerated this process, compromising the therapeutic efficacy of these drugs and generating health, economic, and political consequences on a global scale. In this context, the "responsible use of antimicrobials" emphasizes the commitment, shared responsibility, and conscious action of all actors involved in the life cycle of these medications, as part of an urgent and sustained systemic response to this crisis. This narrative review explores the impact of AMR in Latin America and Argentina, the use of antimicrobials in animal health, and its impact on the environment, proposing various strategies for change. This document serves as a compelling call to action, recognizing the ubiquitous involvement of all stakeholders -the community (including the environment) and the healthcare sector- as both contributors to and potential mitigators of AMR. Ensuring a future where antimicrobials remain effective tools for human, animal, and environmental health is a collective mission for all.
Insights
Antimicrobial resistance (AMR) is a global crisis accelerated by antibiotic misuse. Responsible antimicrobial use by all stakeholders is crucial for preserving drug efficacy in human, animal, and environmental health.
Area of Science:
- Global Health
- Environmental Science
- Microbiology
Background:
- Antimicrobial resistance (AMR) is a significant worldwide threat, exacerbated by extensive and inappropriate antibiotic consumption.
- Microbial resistance is a natural adaptation, but human activities have drastically sped up this process, diminishing drug effectiveness and causing widespread health, economic, and political repercussions.
Purpose of the Study:
- To review the impact of AMR in Latin America and Argentina.
- To examine antimicrobial use in animal health and its environmental consequences.
- To propose strategies for responsible antimicrobial stewardship.
Main Methods:
- This study is a narrative review.
- It synthesizes information on AMR, antibiotic use in various sectors, and environmental impacts.
- It identifies key stakeholders and proposes actionable strategies.
Main Results:
- The review highlights the significant impact of AMR in Latin America, particularly Argentina.
- It underscores the role of antimicrobial use in animal health and its environmental dissemination.
- Various strategies for mitigating AMR are proposed, emphasizing collective responsibility.
Conclusions:
- Addressing AMR requires a systemic response involving all actors, including the community, healthcare sector, and environment.
- Responsible antimicrobial use is essential to maintain the effectiveness of these vital medications.
- A collective mission is needed to ensure antimicrobials remain effective for human, animal, and environmental well-being.
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