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Reframing diet assessment for geroscience: development and preliminary validation of an anti-aging dietary score
Shixing Feng1,2,3,4, Tianyi Wang5, Jinlong Yan6
1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China. fsx@bucm.edu.cn.
Abstract:
Conventional dietary indices often fail to align with aging biology. To bridge this mechanistic gap, we propose the Nutrient-Signaling-Senescence (NSS) axis as an integrative framework. Based on this foundation, we develop the anti-aging dietary score (AADS). Preliminary validation using NHANES data demonstrates that a higher AADS is significantly associated with lower PhenoAge acceleration, performing comparably to established indices. This framework enables translating aging biology into population-based research.