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Introducing Point Mutations into Human Pluripotent Stem Cells Using Seamless Genome Editing
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Generation and characterization of a human induced pluripotent stem cell line (SNUi001-A) harboring the MT-ND4

Hun Ji Choi1, Young Sam Im2, Taehun Yoon1

  • 1Interdisciplinary Program in Stem Cell Biology, College of Medicine, Seoul National University, Seoul, the Republic of Korea.

Stem Cell Research
|June 23, 2026
PubMed

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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.